Objective and noninvasive imaging of embryo characteristics allows detection of abnormal cleavages leading to the occurence of chromosomal malsegregation which are a major cause of spontaneous miscarriage or birth defects
Scanning and analyzing embryo development is a breakthrough approach in
assessing human embryos in a culture medium. It is performed by a computer which
continuously monitors the embryo’s development. The embryos are not
disturbed during their extracorporeal development by constant examinations as
the entire monitoring process happens behind closed doors of the incubator.
Subsequent analysis is based on acquired digital records.
The developmental abilities of human embryos can be predicted by measurement of their cell cycles. Continuous non-invasive embryo monitoring allows an exact measurement of these phases of human embryo development. The duration of the first 4 interphases and synchrony of the daughter cells cleavages are expressed in Embryo Cleavage Rating (ECR) and correspond with regular ooplasmic metabolits and organelles distribution and with embryonic genome activation (EGA).
NON-INVASIVE ALEUPLOIDY PREDICTION – examples