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Treatments & Methods

Our goal is not only a positive pregnancy test. We want to make sure that the entire treatment process leads to a healthy pregnancy and baby.

IVF (In Vitro Fertilization) is a process of fertilization outside the body. The goal is to reach fertilization by placing sperm and oocytes together and letting them interact “in vitro”. The process is technically similar to regular fertilization, except it occurs in a laboratory environment.

However, this method of spontaneous fertilization that has been commonly used in IVF treatments can bring some challenges such as lower fertility rate or a penetration of more than one sperm into the egg. For these reasons, specific laboratory methods of fertilization are implemented in IVF treatments in order to eliminate the challenges we mentioned.

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ICSI IVF with own oocytes

Every couple we treat is unique. Correct evaluation and diagnosis by our doctors ensures that the treatment methods they recommend will specifically suit you. Carefully chosen methods pave the way to our goal: your healthy and successful pregnancy.

IVF with ICSI -all lab methods
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IVF with donation

IVF with donated egg cells is proven to be a very successful fertility treatment. Oocytes from an anonymous and healthy donor get fertilized using your partner’s or donor’s sperm. The embryos, after the cultivation period, are transferred into the recipient’s womb. The remaining embryos are frozen for future transfers.

Donation programmes
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COMBI IVF

This IVF cycle is suitable for couples who are not completely decided to conceive with the help of an Egg donor. They would still like to give their own cells a last chance.

COMBI Cycle
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Social Freezing

Social freezing or Fertility Preservation is the process of freezing your eggs or sperm at your peak fertile age so you can plan parenthood on your own personal and professional terms.

Social freezing.
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Our
methods

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Sperm selection
and fertilization

ICSI - ICSI +

ICSI

ICSI is a procedure used in IVF treatment that dramatically increases the chance of egg fertilization. It has become the most common method of fertilization and it is a standard fertilization method in our clinic.

We prefer to do it even when the sperm analysis of the male partner is normal. ICSI is performed by injecting a single sperm cell into an oocyte and it has proven revolutionary in solving the problems of male infertility.

ICSI
MICHSS - Microfluidic Chip-Based Sperm Sorting +

Microfluidic Chip-Based Sperm Sorting

Unlike traditional centrifugation methods, MICHSS or MSS is a less traumatic sperm selection method shown to decrease DNA fragmentation and thus, increase fertilization results, embryo quality, and pregnancy rates.

It is estimated that 50% of infertility cases are related to the malefactor and sperm. The separation of the healthiest and best-performing sperm without damaging centrifugation can be a decisive factor in the success of fertility treatment -from IUI to IVF. MICHSS can be used in samples that are viscous, with low concentration, low motility, low volume – or a combination of those properties.

Learn more about MICHSS of MSS here
OptimFert - Optimal Mature Egg Fertilization Time +

Optimal Mature Egg Fertilization Time

OptimFert is our original IVF treatment method and represents just one of the innovations increasing the success of infertility treatment.

In the treatment of infertility, the right time of the highest quality embryo transfer is crucial. For its quality, it is an important moment when the egg is mature enough and be ready for sperm fertilization. It is a completely dominant factor affecting the quality of the embryo.

The OptimFert method is based on the oocytes monitoring, i.e. mature eggs, in a laboratory environment. It is a non-invasive method using polarizing microscopy, which can be used in treatment cycles with fresh or frozen eggs.

Find more details about OptimFert
LAISS - Laser-Assisted Immotile Sperm Selection +

Laser-Assisted Immotile Sperm Selection

LAISS is a method that has proven beneficial in identifying immotile spermatozoa if they are alive and viable for ICSI method fertilization.

Sperm viability is a prerequisite for successful ICSI treatment, because the injection of a nonviable spermatozoon into an oocyte generally results in fertilization failure. Method is recommended in MESA/TESE IVF cycles and any other cases of immotile spermatozoa.

Find more details on Fertilitypedia
MACS - Magnetic-Activated Cell Sorting +

Magnetic-Activated Cell Sorting

MACS is a method of sperm-selection using magnetic field technology designed to help selectively remove DNA defective sperm.

The procedure begins with magnetic labelling of unwanted cells and then they are passed through a separation column where they are selectively retained. Living spermatozoa without DNA defection pass through to be used later for ICSI fertility method or cryopreservation.

Find more details on Fertilitypedia

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Embryo selection
for transfer

Astec CCM-IBIS - Continuous time-lapse Embryo monitoring +

Continuous time-lapse Embryo monitoring

Astec CCM-IBIS is top-of-the-line continuous time-lapse monitoring technology. It is built with grade A Japanese steel and it offers a robust built-in gas mixing system to allow us to monitor every stage of development of your embryos. With CCM-IBIS, our lab technicians can have maximum stability and steadiness while working with your embryos; we can monitor each of them individually, without disturbing the rest.

CCM-IBIS is top-of-the-line continuous time-lapse monitoring technology. It is built with grade A Japanese steel and it offers a robust built-in gas mixing system to allow us to monitor every stage of development of your embryos. With CCM-IBIS, our lab technicians can have maximum stability and steadiness while working with your embryos; we can monitor each of them individually, without disturbing the rest.

EmbryoScope® +

Selecting good-quality embryos for the transfer is one of the key processes in IVF treatment.

Making a good choice of embryos can save the patients both time and money and ensures an easier route to the desired pregnancy. That is why we use EmbryoScope for embryo monitoring. Benefits of EmbryoScope:

  • noninvasive, real-time monitoring and evaluation of embryos
  • ability to reveal defects in cellular division of embryos
  • ability to discover poor-quality embryos and discard them before the transfer

Thanks to EmbryoScope, it is possible to monitor and fully control embryo development while selecting the best ones for transfer or freezing.

Find more details on Fertilitypedia
Prolonged Cultivation - Prolonged Embryo Cultivation Period +

Prolonged Embryo Cultivation Period

Cultivation period of an embryo in lab environment is usually around 3 days which is the time period from the fertilization and the transfer.

In certain cases, embryologists recommend prolonged cultivation in order to select the best embryos for the transfer, especially in cases when the doctor recommends single embryo transfer and there are many embryos to choose from. Prolonged cultivation period, which lasts 5 days, allows us to discard, with more ease and accuracy, the embryos that develop in an unsatisfactory manner and choose the good-quality ones for the transfer and freezing.

Find more details on Fertilitypedia

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Assistance for
embryo implantation

LAZT - Laser-Assisted Zona Thinning +

Laser-Assisted Zona Thinning

An embryo is surrounded by a layer called the zona pellucida and when the embryo starts hatching this layer starts to get thinner and eventually decomposes. When performing laser-assisted zona thinning, we make sure that the embryo spends less energy when hatching by getting out of its shell with more ease and eventually implanting itself.

The embryologists use laser technology in order to make the zona pellucida thinner. This method ensures embryo implant more easily which brings more chances for a successful pregnancy.

Find more details on Fertilitypedia
EmbryoGlue® +

EmbryoGlue® is a medium used exclusively during transfer and its use has been shown to increase the chances for successful implantation of an embryo.

EmbryoGlue® contains hyaluronan and recombinant human albumin and it mimics the conditions of the uterus. The medium makes communication between embryos and the endometrium easier and helps embryos implant after transfer.

Find more details on Fertilitypedia

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Endometrial receptivity
and implantation window

ASET - Asynchronous Embryo Transfer +

Asynchronous Embryo Transfer

ASET is recommended by our doctors when they suspect that the reason for the patient not getting pregnant, is due to the endometrial factor. It can happen that the endometrium is not receptive to the embryo as the window of the implantation of the endometrium can vary from cycle to cycle.

With this method, what we do is transfer different embryos of different age by postponing some of them before the transfer with vitrification. By transferring the embryos of different age, we help the endometrium be more receptive in the hope of successful implantation.

ERA - ERA test +

ERA test

ERA test (Endometrial Receptivity Array) is a molecular diagnostic test used to assess endometrial status and to determine whether or not the patient’s endometrium (uterine lining) had a receptive state (seen from the gene profile) at the time of sampling before embryo transfer.

Usually, the optimal endometrial status for embryo transfer are assessed by ultrasound, but it can only reveal its thickness and structure. The ERA test requires an endometrial biopsy that should be carried out seven days after the luteinizing hormone (LH) surge in a natural cycle or after five full days of progesterone exposure in an artificial cycle. The test determines the expression level of 236 genes that are involved in endometrial receptivity at a molecular level. The results will indicate the time at which embryo transfer should be performed in order to increase the pregnancy chances.

Find out more about ERA test
Specific laboratory methods
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Sperm selection and fertilization
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Embryo selection for transfer
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Assistance for embryo implantation
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Endometrial receptivity and implantation window

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