Combined IVF Cycle In Prague, Czech Republic - PFC

Combined IVF cycle 

This type of IVF cycle uses both your eggs and the eggs of a specially selected donor. We fertilise all the eggs in the laboratory using your partner’s sperm. By using this method, we attain a greater number of embryos and can then use the best quality ones for fertilisation.

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How does the treatment work? 

The combined IVF cycle is broadly the same as the IVF process using your own eggs. We also, however, fertilise the eggs of the selected donor at the time of collection and fertilisation of your eggs. This gives us a better chance of obtaining promising embryos for transfer.

You will be guided through the entire process by a personal IVF coordinator and your treatment will be led by a dedicated doctor. For more information on the treatment process, please see our FAQ section.

Preparatory phase 


Consultation with a doctor 

At the inital consultation with your doctor, you will discuss your personal medical history and plan the necessary examinations (or review the examinations that have already been conducted). This is necessary to determine an individual treatment plan. You can complete the examinations in your home country and send us the results securely via our patient portal.

The woman’s examination in this case consists of a gynaecological examination, ultrasound examination and blood sampling to examine the thyroid gland, sexually transmitted diseases and to determine the hormonal profile. The male examination includes a spermogram and a blood test for sexually transmitted diseases.

During the consultation, the doctor will also explain everything you need to know about the fertilisation process of the donated egg. We always prefer, to transfer your own embryos rather than embryos from donated eggs. However, the decision is always an individual one and it is entirely up to you which option you choose. You can rest assured that in every case we will provide you with personalised care with the absolute maximum support and information.

Donor selection 

Based on your phenotype (hair, eye, skin colour, height, etc.), blood type and other possible preferences you may have, we will select a suitable egg donor from our extensive database. All donors are screened medically, genetically and psychologically.

Hormonal stimulation 

Day 2 – 3 of the cycle 

Hormonal stimulation 

After analysing the results obtained from the initial examinations, the doctor will design an individual stimulation protocol. This will allow the development and retrieval of more eggs which are usable for fertilisation. During conventional hormonal stimulation, you will apply the medication for 8 to 10 days.

Egg retrieval and fertilisation 

Day 10 – 15 of the cycle 

Egg retrieval (oocyte pick-up, OPU

On the basis of an ultrasound examination, which can take place either at your gynaecologist or at Prague Fertility Centre, approximately after one week of stimulation, the doctor will determine the appropriate date for egg retrieval. The procedure will take place at our clinic and under a short anaesthetic, the doctor will retrieve the eggs that have been created. You can then go home after a short bed rest.

Fertilisation and cultivation of eggs 

Our embryologists will fertilise your own eggs and donor eggs on the day of collection with your partner’s most viable sperm. The embryooligists use the ICSI method, which involves injecting the selected sperm directly into the egg.

To increase the chances of successful treatment, you may choose to use other laboratory methods.

With the MICHSS method, for example, we can better select the most suitable sperm for fertilisation. This is done using a microfluidic chip, which mimics the environment inside the fallopian tubes and allows only the best quality sperm to pass through the membrane.

Even for couples where 100% of the sperm in the sample is immobile
, we have a solution in the form of the LAISS method (laser-assisted immotile sperm selection). Using a laser, the embryologist searches for immobile but viable sperm, which are then used for fertilisation.

After fertilisation, the embryos develop, cultivating in our laboratory for several days. We can also use an innovative method to monitor embryos, time-lapse monitoring (EmbryoScope). This allows continuous monitoring of the embryos by a camera, without the need for unnecessary manipulation.

Embryo Transfer 

5 Days after retrieval 

Embryo Transfer 

During cultivation, we monitor how the embryos, both from your own and donated eggs, develop. Based on the quality and growth of the embryos, the embryologist determines the date of the transfer of the embryo into your uterus. Before the transfer, the embryologist will give you information about the embryo development process and also answer all your questions so that you can decide which embryo, either one of your own or a donated one, to use for the transfer.

The transfer itself is a quick and painless procedure under ultrasound control. After a short rest you can leave the clinic.

We freeze other high-quality embryos using the vitrification method and you can use them for future treatment if necessary.

After the embryo transfer 

14 Days after transfer 

After the embryo transfer 

After the egg transfer, follow the recommended resting regime. Avoid major physical activity, sexual intercourse and staying in hot environments such as baths or saunas.

You can take a pregnancy test 14 days after the transfer, and you should contact us, whatever the result. If the test is positive, you and your doctor will schedule an ultrasound appointment at our clinic.

If the urine pregancy test is negative, your doctor will recommend a blood test to verify the result. If the blood test is also negative, your doctor will arrange to stop the medication and schedule a follow-up appointment with your doctor to plan your next course of action together.

What is the success rate of treatment 

We can help up to 90% of couples 

Thanks to our individual approach and the combination of assisted reproduction methods, we can help up to 90% of couples within 4 cycles. However, patience, openness and mutual trust are needed. The success rate of a single cycle decreases with age, but can be increased, for example, with preimplantation genetic testing (PGT) of embryos. The graph shows our average success rate of pregnancy per cycle.

According to the age of the patient 

54 % 

<35 years 

47 % 

35 – 40 years 

26 % 

>40 years 

72 % 

>40 with PGT 

We can help up to 90% of couples 

Thanks to our individual approach and the combination of assisted reproduction methods, we can help up to 90% of couples within 4 cycles. However, patience, openness and mutual trust are needed. The graph shows our average success rate per cycle.

By type of cycle 

69 % 

Donated eggs 

80 % 

Donated embryos 

The clinic that understands your needs 

We run our own donor programme 

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At PFC Clinic, we have our own donor programme with a large database of anonymous, vetted donors. Egg donation in the Czech Republic is strictly anonymous. Couples can only find out basic information about the donor regarding biological characteristics. As this is a very sensitive issue, we carefully select the donor for the couple based on basic physical features, blood type and possibly other specific preferences of the couple. We have many years of experience in selecting egg donors and have matched them to help thousands of couples.

Who are our donors

  • Young women (typically aged between 21 – 33 years)
  • The women are physically healthy
  • The women are mentally healthy
  • The women have a body mass index (BMI) below 30

Every woman interested in donating

  • Must undergo rigorous genetic testing
  • Complete a comprehensive medical examination
  • Undergo a check of her family’s medical history.


How do the mother’s genes affect the donated egg? 

One of your questions when deciding whether to choose egg donation is, how and if the mother’s genes can affect the donated egg? New studies show that you, as the recipient, can affect the gene expression of the baby from the donated egg in two ways. The first is epigenetics, which studies changes caused by molecules in the womb other than DNA help. These can affect the embryo before implantation. The second way is lifestyle, which affects every pregnancy, and a responsible attitude will positively affect your baby, ensuring an optimal environment for development.

How much does IVF with donor eggs cost? 

The price of IVF with donated eggs is higher than methods with your own eggs because it covers the costs associated with the donor, including her selection, examination, hormonal stimulation and egg retrieval. You are, however, guaranteed 2 embryos suitable for transfer included in the price.

Price list for IVF with donated eggs

Behind every success is an expert team 

An expert team including an experienced doctor, embryologist and a personal IVF Coordinator has your health as its first priority and works to ensure the best possible results.