Laser-Assisted Frozen Embryo Transfers In Europe - PFC

assisted hatching

Laser-assisted hatching, or LAZT, is an advanced laboratory method that helps an embryo leave its shell and successfully nest. LAZT is a good choice to facilitate implantation. Various studies show that assisted hatching significantly reduces the time it takes for an embryo to leave its shell, thus increasing its nesting success rate.

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What is LAZT?

Breaking free from its protective shell is necessary for successful embryo settlement in the uterus.

On days 5 – 6 of embryo development, it is time for the embryo to leave the shell’ or zona pellucida that has protected it until then. This process, known as hatching’, is necessary for the embryo to come into contact with the cells of the uterus in which it is to nest.

Repeated failure of embryo implantation
is, in some cases, caused by its inability to leave the outer layer that protects it. This may be due to the weakening of the embryo or changes to the shell itself, such as hardening caused by freezing and thawing. 

In such cases, we can thin the zona pellucida in a well-defined safe area using LAZT. This is essentially using a non-contact laser to facilitate hatching to increase the likelihood of successful nesting.

Main benefits of LAZT

  • The internal environment of the embryo remains protected and intact.
  • There is no risk of inflammation due to the direct activity of white blood cells.
  • The entire laser process is continuously monitored.
  • There is no increased possibility of the formation of identical (monozygotic) twins.
  • Negative mechanical, thermal and genotoxic effects are eliminated.

Lasser-assisted hatching | PFC

Are you interested in laser-assisted hatching and its possibilities in promoting successful embryo nesting? PFC was the first assisted reproduction centre in the Czech Republic to introduce this state-of-the-art non-contact laser technology into clinical use. Our embryologists have many years of experience with LAZT embryo hatching and can introduce you to this method. 

Contact our IVF coordinators and schedule a call with our IVF-specialist to learn more about what laboratory methods would be most useful for your particular situation.