Laser-assisted hatching, or LAZT, is an advanced laboratory method that helps an embryo leave its shell and successfully nest. LAZT is a good choice to facilitate implantation. Various studies show that assisted hatching significantly reduces the time it takes for an embryo to leave its shell, thus increasing its nesting success rate.
Breaking free from its protective shell is necessary for successful embryo settlement in the uterus.
On days 5 – 6 of embryo development, it is time for the embryo to leave the ‘shell’ or zona pellucida that has protected it until then. This process, known as ‘hatching’, is necessary for the embryo to come into contact with the cells of the uterus in which it is to nest.
Repeated failure of embryo implantation is, in some cases, caused by its inability to leave the outer layer that protects it. This may be due to the weakening of the embryo or changes to the shell itself, such as hardening caused by freezing and thawing.
In such cases, we can thin the zona pellucida in a well-defined safe area using LAZT. This is essentially using a non-contact laser to facilitate hatching to increase the likelihood of successful nesting.
Lasser-assisted hatching | PFC
Are you interested in laser-assisted hatching and its possibilities in promoting successful embryo nesting? PFC was the first assisted reproduction centre in the Czech Republic to introduce this state-of-the-art non-contact laser technology into clinical use. Our embryologists have many years of experience with LAZT embryo hatching and can introduce you to this method.
Contact our IVF Coordinators and schedule a call with our IVF-specialist to learn more about what laboratory methods would be most useful for your particular situation.
An innovative polarising microscopy method for monitoring egg maturity to determine the correct timing for fertilisation.
A special solution for protecting the embryo and facilitating its connection with the uterine lining.
A real-time embryo development tracking system to select the embryos with the highest potential for nesting.
Preimplantation genetic screening and diagnosis — prevention of nesting failure and transmission of genetic defects.
Modern microsurgical sperm collection methods from the testicles and epididymis in the case of low / zero sperm concentration.
Selection of the best quality sperm based on concentration and motility using a microfluidic chip.
Intracytoplasmic injection of sperm directly into the egg in order to overcome barriers and increase chances of fertilisation.
Monitored embryo development over 48 hours to select the embryo with the highest potential for implantation.
Asynchronous embryo transfer is a method in which we transfer 2 embryos of different ages to increase chances of succesful implantation.
ERA test, beReady — advanced analytical methods of the genetic profile of the uterine lining to determine the timing of implantation.
Preservation of eggs and embryos for potential future use by fast, gentle and efficient freezing.